Dr. YSHTD Silva

PhD (USJP), MBBS (UOD, UK), MSc (UCL, UK), BSc (QMUL, UK)
Senior Lecturer in Biochemistry
Subject Head – Biochemistry
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Qualifications
Research Interests
Teaching Areas
Publications
Other Responsibilities
Involvement with other Organizations
Awards & Grants
  • Qualifications

  • Qualifications

    • PhD University of Sri Jayawardanapura (2022)
    • Certificate in Teaching in Higher Education (CTHE) - General Sir John Kotelawala Defence University; 2022.
    • Diploma in Clinical Education Royal College of Physicians Glasgow, Scotland, UK; 2014.
    • MBBS - University of Dundee, UK; 2012.
    • MSc Molecular Medicine - University College London; 2007.               
    • BSc Biochemistry - Queen Mary University, London; 2006.
  • Research Interests

  • Research Interests

    • Infectious disease - Dengue
  • Teaching Areas

  • Teaching Areas

    • Clinical Biochemistry
    • Immunology
    • Nutrition
  • Publications

  • Publications

    Referred Journal Articles

    • Dayarathna S, Kuruppu H, Silva T, Gomes L, Shyamali ALN, Jeewandara C, Ariyaratne D, Ramu ST, Wijewickrama A, Ogg GS, Malavige GN. Are viral loads in the febrile phase a predictive factor of dengue disease severity- BMC Infectious Diseases (2024) 24:1248. https://doi.org/10.1186/s12879-024-10152-2
    • Fonseka CL, Hardman CS, Woo J, Singh R, Nahler J, Yang J, Chen YL, Kamaladasa A, Silva T, Salimi M, Gray N, Dong T, Malavige GN, Ogg GS. Dengue virus co-opts innate type 2 pathways to escape early control of viral replication. Commun Biol.2022 Jul 22;5(1):735. doi:10.1038/s42003-022-03682-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306424/
    • Silva T, Gomes L, Jeewandara C, Ogg GS, Malavige GN. Dengue NS1 induces phospholipase A2 enzyme activity, prostaglandins, and inflammatory cytokines in monocytes. Antiviral Res. 2022 Jun;2202:105312. doi: 10.1016/j.antiviral.2022.105312. Epub 2022 Apr 5.
      https://pubmed.ncbi.nlm.nih.gov/35395274/
    • Tehani Silva, Chandima Jeewandara, Laksiri Gomes, Chathurika Gangani, Ananda Wijewickrama, Graham S. Ogg, Gathsaurie Neelika Malavige. (2021) Urinary leukotrienes and histamine in patients with varying severity of acute dengue. PLoS One 5;16(2): e0245926. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864425/

    Communications at scientific meetings published as Abstracts

    • Silva T, Fonseka CL, Jeewandara C, Wijewickrama A, Ogg GS, Malavige GN. Prostaglandin D2 and E2 in acute dengue and the role of non-structural protein 1 in inducing their production in monocytes. International Research and Innovation Symposium; “Dengue amidst the pandemic” 16th-17th March 2022, Colombo.
    • Silva T, Gomes L, Jeewandara C, Ogg G & Malavige G.N. Dengue NS1 antigen induce phospholipase A2 enzymes and inflammatory cytokines production in primary human monocytes. British Society of Immunology Congress 2021; poster presentation.
    • Tehani Silva, Chandima Jeewandara, Graham Ogg & Gathsaurie Neelika Malavige. Activation of monocytes by Dengue NS1 antigen leads to the production of secretory and cytoplasmic phospholipase A2 Poster presentation at the 21st Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS) 2021; poster presentation.
    • Silva T, Gomes L, Mahapatuna SD, Thilagaraj P, Jeewandara C, Wijewickrama A, Ogg G, Malavige GN. Urinary histamine in patients with varying severity of acute dengue. Ceylon College of Physicians annual virtual conference 2020; oral presentation.
    • Silva Y.S.H.T.D, Gomes L, Mahapatuna S.D, Wickramatunga, C.K, Jeewandara C, Wijewickrama A, Ogg G, Malavige G.N. Urinary Leukotriene E4 levels as a biomarker of disease severity in patients with acute dengue infection. British Society of Immunology Congress 2019; poster presentation.
  • Other Responsibilities

  • Other Responsibilities

    • In charge Research Laboratory (BML-1) (since July 2024)
    • Academic Counselor for the subject Biochemistry (since July 2024)
    • Committee member Ethics Review Committee (since April 2024)
    • Committee member Research Cell (since July 2024)
    • Subject Head Biochemistry, Department of Pre-Clinical Science (since June 2023)
    • Committee member CD & EC (since June 2023)
    • Convener- Foundation Program for Intake 39, Faculty of Medicine, KDU, 2021 
    • Co-coordinator for the Faculty of Medicine- International Research Conference - KDU 2017
    • Main coordinator for the Faculty of Medicine, Pre-congress seminar- International Research Conference- KDU 2017
    • Secretary- Faculty of Medicine, Newsletter; 2016- 2019
  • Involvement with other Organizations

  • Involvement with other Organizations

    • Member of the British Society of Immunology (from 2019-2021)
    • Member of the British Society of Immunology (since 2019).
    • General Medical Council, UK (since 2014): GMC number: 7266161.
  • Awards & Grants

  • Awards & Grants

    • 2022 Best oral presentation under the theme of clinical management of dengue and covid-19 during the pandemic at the International Research and Innovations Symposium on Dengue amidst the Pandemic March 2022 organized by the National Dengue Control Unit Sir Lanka.
    • 2007 Recipient of Dr R.D Campbell Memorial prize for the best final year medical student performance in Phase 3 Laboratory study for Biochemical Medicine, University of Dundee, UK.